NR3C2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comNR3C2 Polyclonal Antibody for Human(Homo sapiens)

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NR3C2 (Gene name),

Mineralocorticoid receptor (Protein name ), MCR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

NR3C2(MCR;MLR);

Protein name:

Mineralocorticoid receptor(MR);

Alternative:

Nuclear receptor subfamily 3 group C member 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.

Function:

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Subcellular Location:

Cytoplasm Nucleus Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.

Protein Attributes:

Sequence length:

984

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

984:

ALKVEFPAML | VEIISDQLPK | VESGNAKPLY | FHRK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P08235

STRING:

9606.ENSP00000350815

UniGene:

Hs.163924

Pfam:

PF00104

MIM:

177735

String:

P08235

KEGG:

hsa:4306

Uniprot:

P08235

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ELISA Kit for Human MR

Cat.:

E0158r

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Packing:

96T

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ELISA Kit for Human MR

Cat.:

E0158m

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96T

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ELISA Kit for Human MR

Cat.:

E0158h

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96T

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ELISA Kit for Human MR

Cat.:

E0158c

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96T

ELISA Kit for Human MR

Cat.:

E0158p

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Packing:

96T

CLIA Kit for Human MR

Cat.:

U0158c

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96T

CLIA Kit for Human MR

Cat.:

U0158p

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Packing:

96T

CLIA Kit for Human MR

Cat.:

U0158m

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MSDS:

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96T

CLIA Kit for Human MR

Cat.:

U0158h

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96T

CLIA Kit for Human MR

Cat.:

U0158r

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96T

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Polyclonal Antibody for Human MR

Cat.:

P0158Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MR

Cat.:

P0158Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MR

Cat.:

P0158Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human MR

Protein for Human MR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor."
Arriza J.L. , Weinberger C. , Cerelli G. , Glaser T.M. , Handelin B.L. , Housman D.E. , Evans R.M.
Science237:268-275(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
tissue: Kidney.
2.

"A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action."
Zennaro M.-C. , Souque A. , Viengchareun S. , Poisson E. , Lombes M.
Mol. Endocrinol.15:1586-1598(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4);TISSUE SPECIFICITY;INTERACTION WITH NCOA1; TIF1 AND NRIP1;VARIANTS VAL-180 AND VAL-241
tissue: Heart.
3.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2008-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-180 AND VAL-241
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS VAL-180 AND VAL-241
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANTS VAL-180 AND VAL-241
6.

"Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I."
Geller D.S. , Rodriguez-Soriano J. , Vallo Boado A. , Schifter S. , Bayer M. , Chang S.S. , Lifton R.P.
Nat. Genet.19:279-281(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 545-984;DISEASE
7.

"Overexpression and characterization of the human mineralocorticoid receptor."
Alnemri E.S. , Maksymowych A.B. , Robertson N.M. , Litwack G.
J. Biol. Chem.266:18072-18081(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION
8.

"Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects."
Hanukoglu A.
J. Clin. Endocrinol. Metab.73:936-944(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEFINITION OF DIFFERENT FORMS OF PSEUDOHYPOALDOSTERONISM TYPE 1
9.

"Identification of a splice variant of the rat and human mineralocorticoid receptor genes."
Bloem L.J. , Guo C. , Pratt J.H.
J. Steroid Biochem. Mol. Biol.55:159-162(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 3)
tissue: Leukocyte.
10.

"Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states."
Zennaro M.-C. , Farman N. , Bonvalet J.-P. , Lombes M.
J. Clin. Endocrinol. Metab.82:1345-1352(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
11.

"The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52."
Bruner K.L. , Derfoul A. , Robertson N.M. , Guerriero G. , Fernandes-Alnemri T. , Alnemri E.S. , Litwack G.
Recept. Signal Transduct.7:85-98(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TERNARY COMPLEX WITH HSP90; HSP70 AND FKBP4;DISSOCIATION UPON ALDOSTERONE BINDING
12.

"Cysteines 849 and 942 of human mineralocorticoid receptor are crucial for steroid binding."
Lupo B. , Mesnier D. , Auzou G.
Biochemistry37:12153-12159(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-808; CYS-849 AND CYS-942
13.

"Mechanistic aspects of mineralocorticoid receptor activation."
Hellal-Levy C. , Fagart J. , Souque A. , Rafestin-Oblin M.-E.
Kidney Int.57:1250-1255(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-770; GLN-776; ARG-817 AND THR-945
14.

"Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor."
Hellal-Levy C. , Fagart J. , Souque A. , Wurtz J.-M. , Moras D. , Rafestin-Oblin M.-E.
Mol. Endocrinol.14:1210-1221(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA1; TIF1 AND NRIP1;MUTAGENESIS OF LEU-952; LYS-953; VAL-954; PHE-956 AND PRO-957
15.

"The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2."
Odermatt A. , Arnold P. , Frey F.J.
J. Biol. Chem.276:28484-28492(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH HSD11B2
16.

"Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease."
Shibata S. , Nagase M. , Yoshida S. , Kawarazaki W. , Kurihara H. , Tanaka H. , Miyoshi J. , Takai Y. , Fujita T.
Nat. Med.14:1370-1376(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
17.

"A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor."
Bledsoe R.K. , Madauss K.P. , Holt J.A. , Apolito C.J. , Lambert M.H. , Pearce K.H. , Stanley T.B. , Stewart E.L. , Trump R.P. , Willson T.M. , Williams S.P.
J. Biol. Chem.280:31283-31293(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 712-984 OF MUTANT SER-808 IN COMPLEXES WITH AGONIST AND ANTAGONISTS;CHARACTERIZATION OF VARIANT EOHSEP LEU-810;MUTAGENESIS OF SER-767; ASN-770 AND THR-945
18.

"Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor."
Li Y. , Suino K. , Daugherty J. , Xu H.E.
Mol. Cell19:367-380(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 732-984 OF MUTANT SER-808 IN COMPLEX WITH STEROID LIGAND AND NCOA2;SUBUNIT;MUTAGENESIS OF LYS-782; LYS-785 AND GLU-796
19.

"Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension."
Fagart J. , Huyet J. , Pinon G.M. , Rochel M. , Mayer C. , Rafestin-Oblin M.-E.
Nat. Struct. Mol. Biol.12:554-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 731-984 OF MUTANT LEU-810 IN COMPLEXES WITH STEROID AGONISTS;CHARACTERIZATION OF VARIANT EOHSEP LEU-810;MUTAGENESIS OF GLN-776 AND ARG-817
20.

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-180; THR-444; GLN-537 AND SER-554
21.

"A novel missense mutation of mineralocorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism type 1."
Tajima T. , Kitagawa H. , Yokoya S. , Tachibana K. , Adachi M. , Nakae J. , Suwa S. , Katoh S. , Fujieda K.
J. Clin. Endocrinol. Metab.85:4690-4694(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT PHA1A PRO-924
22.

"Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy."
Geller D.S. , Farhi A. , Pinkerton N. , Fradley M. , Moritz M. , Spitzer A. , Meinke G. , Tsai F.T.F. , Sigler P.B. , Lifton R.P.
Science289:119-123(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EOHSEP LEU-810;MUTAGENESIS OF SER-810
23.

"Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism."
Arai K. , Nakagomi Y. , Iketani M. , Shimura Y. , Amemiya S. , Ohyama K. , Shibasaki T.
Hum. Genet.112:91-97(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS VAL-180 AND VAL-241
24.

"Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism."
Sartorato P. , Lapeyraque A.-L. , Armanini D. , Kuhnle U. , Khaldi Y. , Salomon R. , Abadie V. , Di Battista E. , Naselli A. , Racine A. , Bosio M. , Caprio M. , Poulet-Young V. , Chabrolle J.-P. , Niaudet P. , De Gennes C. , Lecornec M.-H. , Poisson E. , more...
J. Clin. Endocrinol. Metab.88:2508-2517(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS PHA1A ARG-633; ARG-776; PRO-924 AND PRO-979
25.

"Elucidating the underlying molecular pathogenesis of NR3C2 mutants causing autosomal dominant pseudohypoaldosteronism type 1."
Riepe F.G. , Finkeldei J. , de Sanctis L. , Einaudi S. , Testa A. , Karges B. , Peter M. , Viemann M. , Groetzinger J. , Sippell W.G. , Fejes-Toth G. , Krone N.
J. Clin. Endocrinol. Metab.91:4552-4561(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS PHA1A LEU-818 AND GLY-972
26.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-7
27.

"Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism."
Pujo L. , Fagart J. , Gary F. , Papadimitriou D.T. , Claes A. , Jeunemaitre X. , Zennaro M.-C.
Hum. Mutat.28:33-40(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHA1A SER-645; SER-659; SER-759; PRO-769; LYS-770; PRO-805 AND ARG-815

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